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1988年5月～1996年1月,我们收治新生儿中度硬肿症87例,重度33例,运用改良肝素法治疗60例,报告如下: 1 一般资料 新生儿中、重度硬肿症120例,男77例.女43例。早产儿64例,低出生体重儿48例(足月小样儿4例),极低出生体重儿5例,合并肺出血20例,其他部位出血10例,播散性血管内凝血(DIC)3例。 2 方法与结果 将120例新生儿中、重度硬肿症随机分为两组。对照组:60例,肝素加一般治疗,肝素首剂1 mg/kg～1.5 mg/kg,以后0.75 mg/kg～1 mg/kg,q6h(重度硬肿症)或q8h(中度硬肿症)一次,随病情改善改为12h一次至每天一次直至停用。治疗组:60例,肝素用法、剂量同前,氨茶碱2mg/(ke·次)～4mg/(kg·次)每6h～8h一次,酚妥拉明0.5mg/(kg·次)～1 mg/(kg·次)每6h～8h一次,强心剂,严
From May 1988 to January 1996, we admitted 87 newborns with moderate sclerosis and 33 severe cases with 60 cases treated with modified heparin. The report was as follows: 1 General Information 120 cases of moderate and severe scleredema in newborns , 77 males and 43 females. 64 preterm infants, 48 low birth weight infants (4 full moons), 5 very low birth weight infants, 20 pulmonary hemorrhage, 10 other bleeding, disseminated intravascular coagulation (DIC) 3 example. 2 Methods and Results 120 cases of newborn, severe sclera were randomly divided into two groups. Control group: 60 cases, heparin plus general treatment, heparin first dose of 1 mg / kg ~ 1.5 mg / kg, after 0.75 mg / kg ~ 1 mg / kg, q6h (severe sclerosis) or q8h ) Once, with the condition improved to 12h once a day until disabled. The treatment group: 60 cases, heparin usage, the same dose, aminophylline 2mg / (ke · times) ~ 4mg / (kg · times) every 6h ~ 8h, phentolamine 0.5mg / (kg · times) ~ 1 mg / (kg · times) once every 6h ~ 8h, cardiac, strict