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目的：了解血管内皮生长因子（ｖａｓｃｕｌａｒｅｎｄｏｔｈｅｌｉａｌｇｒｏｗｔｈｆａｃｔｏｒ，ＶＥＧＦ）在视网膜血管增殖性疾病患者玻璃体中的含量。方法：采用酶联免疫吸附实验（ｅｎｚｙｍｅｌｉｎｋｅｄｉｍｍｕｎｏｓｏｒｂｅｎｔａｓｓａｙ，ＥＬＩＳＡ）测定伴有新生血管的视网膜静脉阻塞（ｒｅｔｉｎａｌｖｅｉｎｏｃｌｕｓｉｏｎ，ＲＶＯ）和视网膜静脉周围炎（Ｅａｌｅｓ病）患者玻璃体ＶＥＧＦ含量。结果：ＲＶＯ患者（７例）和Ｅａｌｅｓ病患者（７例）玻璃体ＶＥＧＦ含量分别为（４．６７±３．３８）ｎｇ／ｍｌ和（１．７９±０．４４）ｎｇ／ｍｌ，是正常人（０．３５±０．１５）ｎｇ／ｍｌ的１３倍和５倍（Ｐ＜０．０１）。结论：ＲＶＯ和Ｅａｌｅｓ病患者玻璃体ＶＥＧＦ水平明显升高，提示ＶＥＧＦ可能参与其眼内新生血管增殖机制。
Objective: To investigate the content of vascularendothelial growth factor (VEGF) in the vitreous of patients with retinal vascular proliferative diseases. Methods: The levels of vitreous VEGF in patients with neovascular retinal vein occlusion (RVO) and retinal vein inflammation (Eales disease) were determined by enzyme linked immunosorbentassay (ELISA). Results: The vitreous VEGF levels in RVO patients (7 cases) and Eales patients (7 cases) were (4.67 ± 3.38) ng / ml and (1.79 ± 0.44) ng / ml, respectively. (0.35 ± 0.15) ng / ml for 13-fold and 5-fold (P <0.01). CONCLUSIONS: The vitreous VEGF levels in patients with RVO and Eales are significantly elevated, suggesting that VEGF may be involved in the pathogenesis of intraocular neovascularization.