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目的探讨ABCB1和ABCC2基因多态性与中国汉族儿童抗结核药物致肝毒性(anti-tuberculosis drug-induced hepatotoxicity,ATDH)易感性的相关性。方法在中国汉族结核病患儿中,采用病例对照研究,利用高通量的Mass ARRAY平台,对于ABCB1和ABCC2基因的16个标签单核苷酸多态性(single nucleotide polymorphisms,SNPs)位点展开基因分型,并采用logistic回归分析以上SNP位点等位基因和基因型频率在ATDH病例组和ATDH对照组中的分布差异。结果本研究共纳入41例ATDH病例以及189例对照。ABCB1和ABCC2基因SNP位点的等位基因以及基因型在两组间频率分布差异均无统计学意义(P>0.05)。SNP位点分别按照显性遗传模型和隐性遗传模型分析,各位点基因型在两组间频率分布差异均无统计学意义(P>0.05)。结论 ABCB1和ABCC2基因多态性可能与中国汉族儿童ATDH的发生并无相关性。
Objective To investigate the association between ABCB1 and ABCC2 gene polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity (ATDH) in Chinese Han children. Methods A case-control study was conducted in children with Han Chinese of Han nationality. Using the high-throughput Mass ARRAY platform, 16 single nucleotide polymorphisms (SNPs) were amplified for ABCB1 and ABCC2 genes Logistic regression analysis was used to analyze the distribution of alleles and genotype frequencies of the above SNP loci in ATDH and ATDH control groups. Results A total of 41 ATDH cases and 189 controls were included in this study. There were no significant differences in the frequency distribution of alleles and genotypes between SNPs of ABCB1 and ABCC2 in both groups (P> 0.05). SNP loci were analyzed according to the dominant and recessive genetic models, respectively. There was no significant difference in genotype distribution between the two groups (P> 0.05). Conclusion The polymorphisms of ABCB1 and ABCC2 may not be associated with the occurrence of ATDH in Chinese Han children.