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应用免疫组织化学技术，观察胃癌组织中bcl-2表达，探讨其临床病理意义。结果显示，bcl-2表达的阳性率为82％，阳性反应物质位于细胞浆或极膜上，胞核中偶有表达。bcl-2在胃癌组织中的表达与病人年龄、性别、肿瘤大小、淋巴结转移、浆膜情况及临床分期无明显关系（P＞0．05）。与胃癌形态学分型及分化程度有明显关系（P＜0．01）。提示bcl－2异常表达与肠型胃癌发生的关系密切，bcl－2在胃癌形成的早期阶段及表型分化中起重要作用，而在胃癌中晚期的作用不明显。
Immunohistochemistry was used to observe the expression of bcl-2 in gastric cancer tissues and its clinicopathological significance was explored. The results showed that the positive rate of bcl-2 expression was 82%, and the positive reaction substance was located on the cytoplasm or the polar membrane and was occasionally expressed in the nucleus. The expression of bcl-2 in gastric cancer was not significantly related to the age, gender, tumor size, lymph node metastasis, serosal condition and clinical stage (P>0.05). There was a significant relationship between the morphological type and differentiation of gastric cancer (P<0.01). It is suggested that the abnormal expression of bcl-2 is closely related to the occurrence of intestinal type gastric cancer. bcl-2 plays an important role in the early stage of gastric cancer formation and phenotypic differentiation, while the role of bcl-2 in gastric cancer is not obvious.