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静脉血管畸形(VMs)对人类健康的危害日益加重，病理机制复杂，其中重症静脉血管畸形综合征尚无根治办法。现有研究证据表明半乳糖凝集素3(Gal-3)与血管生成、静脉血栓形成密切相关，Gal-3在VMs组织中高表达，提示Gal-3可能参与VMs的发生与发展，并促进VMs局部血管内凝血(LIC)。本文拟对Gal-3与VMs的关系作一综述。“,”Venous malformations (VMs) are increasingly harmful to human health with a complex pathological mechanism. Among them, there is no radical cure for severe venous vascular malformation syndrome. Existing research evidences showed that Galectin-3 (Gal-3) is closely related to angiogenesis and venous thrombosis. High expression of Gal-3 in VMs tissues suggests Gal-3 may be involved in the occurrence and development of VMs. It also promoted the local intravascular coagulation (LIC) of VMs. In this paper, we will reveiw the relationship between Gal-3 and VMs.