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基于SPR原理的生物传感技术高灵敏的质量传感特性,具有无需标记、实时监测生物分子间相互作用过程的优点,目前在生物学检测尤其是遗传领域的研究中越来越受到重视,显示出很强的应用潜力。本文介绍了SPR技术的基本理论和应用原理,分析和整理了近年来SPR技术在经典遗传学,表观遗传学,和抗原抗体相互作用的具有代表性的研究结果,以期对近年来SPR技术在生物学领域的应用作一介绍。
The SPR-based high-sensitivity mass sensing of biosensing technology has the advantages of no marking and real-time monitoring of the interaction process of biomolecules. At present, more attention has been paid to the biological detection, especially in the field of genetics, Strong application potential. This paper introduces the basic theory and application principle of SPR technology, analyzes and compiles the representative research results of the SPR technology in classical genetics, epigenetics, and antigen-antibody interaction in recent years, with a view to SPR technology in recent years The field of biology for an introduction.