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由肾小球肾炎和高血压性肾小球硬化所致的终末期肾功能衰竭中男性发病率高于女性。多种肾脏病发展男性快于女性［１］。肾小球硬化包括细胞增殖和细胞外基质合成，我们实验观察性激素对体外培养大鼠肾小球系膜细胞（ＭＣ）增殖和基质合成的直接影响。一、材料和方法１．ＭＣ的
The incidence of end-stage renal failure due to glomerulonephritis and hypertensive glomerulosclerosis is higher in men than in women. A variety of kidney disease development in men than women [1]. Glomerulosclerosis, including cell proliferation and extracellular matrix synthesis, we experimentally observed the direct effects of sex hormones on rat mesangial cell (MC) proliferation and matrix synthesis in vitro. First, materials and methods 1. MC’s