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目的:探讨实施药学干预对儿童抗生素相关性腹泻(antibiotic associated diarrhea,AAD)的影响。方法:随机抽查我院2008年1月～2009年12月儿科呼吸道感染住院的病历,对AAD相关因素进行Logistic回归分析,筛选儿童AAD的危险因素,作为制定相应的药学干预措施的依据。2010年每月随机抽查儿科呼吸道感染住院的病历,对确诊为AAD的病例,采用监测-培训-计划(Monitoring-Training-Plan,MTP)干预模式进行药学干预。结果:患儿的年龄<3岁、抗生素不合理使用是我院儿童AAD的危险因素,微生态制剂应用是其保护因素。药学干预后,抗生素的使用趋向合理,AAD发生率由干预前的39.56%下降至干预后的8.52%(P<0.05),差异有统计学意义。结论:实施有效的药学干预可降低儿童AAD发生,提高治疗质量。
Objective: To investigate the effect of pharmacy intervention on antibiotic associated diarrhea (AAD) in children. Methods: The hospital records of pediatric respiratory infections were randomly selected from January 2008 to December 2009 in our hospital. Logistic regression analysis was performed on the related factors of AAD. The risk factors of AAD in children were screened as the basis for formulating the corresponding pharmacological interventions. In 2010, the hospital records of pediatric respiratory infections were randomly selected every month. For those diagnosed with AAD, the interventions were conducted using the monitoring-training-plan (MTP) intervention model. Results: The age of children <3 years old, irrational use of antibiotics is a risk factor for children with AAD in our hospital, the application of probiotics is its protective factor. The use of antibiotics tended to be rational after the drug was administered. The incidence of AAD decreased from 39.56% before intervention to 8.52% after intervention (P <0.05). The difference was statistically significant. Conclusion: Effective pharmacological intervention can reduce the incidence of AAD in children and improve the quality of treatment.