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用柱状假丝酵母脂肪酶(CRL)对外消旋萘普生甲酯进行手性水解拆分,所得(S)-萘普生粗品经酯化后,继续用CRL进行第二次拆分得到(S)-萘普生。根据建立的理论曲线,在第一次和第二次拆分转化率分别为46.8%和75.1%时终止反应,以31.8%的产率获得了ee值大于99%的(S)-萘普生。
The racemic naproxen methyl ester was subjected to chiral hydrolysis with Candida cylindracea lipase (CRL). The crude product of (S) -naproxen was esterified and the second step was continued with CRL to obtain ( S) -naproxen. According to the established theoretical curve, the reaction was terminated at the first and second split conversion rates of 46.8% and 75.1%, respectively, with (S) -naproxen having ee values greater than 99% in 31.8% yield .