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目的探讨巨细胞病毒(CMV)感染患儿的临床特征、诊治措施和疾病转归。方法回顾性分析57例CMV感染婴幼儿的临床资料及治疗情况。结果 57例CMV感染以呼吸道感染和黄疸为主要表现,还有肝肿大和脾肿大。实验室检查:WBC有2.0%>20×109/L,35%(10~20)×109/L;84%的淋巴细胞比率>60%;21%的PLT<100×109/L;20%的CRP>20 mg/L;肝功异常占67.0%,支气管肺炎占68.0%,肺炎伴胸腔积液1例。用更昔若韦治疗后,呼吸道感染患儿临床症状消失,黄疸者治愈,3例胆汁淤积性改变者病情好转。结论 CMV主要损害肺和肝,更昔若韦是治疗CMV感染的有效药物,CMV肝炎早期使用的疗效更佳,用于治疗CMV感染具有较高的安全性。
Objective To investigate the clinical features, diagnosis and treatment measures and prognosis of children with cytomegalovirus (CMV) infection. Methods Retrospective analysis of 57 cases of CMV infection in infants and young children’s clinical data and treatment. Results 57 cases of CMV infection with respiratory tract infection and jaundice as the main performance, as well as hepatomegaly and splenomegaly. Laboratory tests showed that WBC had 2.0%> 20 × 109 / L, 35% (10 ~ 20) × 109 / L, 84% lymphocyte ratio> 60%, 21% PLT <100 × 109 / L, 20% CRP> 20 mg / L; abnormal liver function accounted for 67.0%, bronchopneumonia 68.0%, pneumonia with pleural effusion in 1 case. After treatment with more Xiwovei, children with respiratory tract infection disappeared, jaundice were cured, 3 cases of cholestatic changes improved. Conclusion CMV mainly damages lung and liver, and ganciclovir is an effective drug for the treatment of CMV infection. CMV hepatitis has better curative effect in the early stage and has higher safety for treating CMV infection.