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为探讨ｐ５３蛋白在胃癌及癌前病变中表达的意义。用ｐ５３蛋白的单抗，采用免疫组化ＬＳＡＢ法检测分析１１８例胃良恶性及癌前病变中ｐ５３蛋白表达。结果显示，正常胃粘膜、胃炎性息肉、轻度异型增生，ｐ５３蛋白均无表达，中重度异型增生、胃癌阳性表达率分别为１４％、４７％。在７４例胃癌中，ｐ５３蛋白阳性表达与胃癌的分化程度、淋巴结转移及浸润深度相关，在相对应组中差异显著（Ｐ＜０．０５）。结果提示ｐ５３异常表达参与了胃癌的发生发展。认为检测ｐ５３蛋白的表达可作为判断胃癌病人预后和指导癌前病变处理的重要指标之一
To explore the significance of p53 protein expression in gastric cancer and precancerous lesions. The p53 protein monoclonal antibody was used to detect the expression of p53 protein in benign, malignant and precancerous lesions by immunohistochemical LSAB method. The results showed that there was no expression of p53 protein in normal gastric mucosa, gastritis polyps, and mild dysplasia. The positive expression rates of moderate-severe dysplasia and gastric cancer were 14% and 47%, respectively. In 74 cases of gastric cancer, the positive expression of p53 protein was related to the degree of differentiation of gastric cancer, lymph node metastasis, and depth of invasion, and it was significantly different in the corresponding group (P<0.05). The results suggest that abnormal expression of p53 is involved in the occurrence and development of gastric cancer. It is thought that the detection of p53 protein expression can be used as one of the important indicators to judge the prognosis of gastric cancer patients and guide the treatment of precancerous lesions.