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目的:探讨美沙拉嗪口服联合灌肠治疗溃疡性结肠炎的临床疗效及安全性。方法:收集2006年1月到2010年12月在我院就诊的溃疡性结肠炎患者60例,随机分为治疗组和对照组,治疗组给予口服美沙拉嗪缓释颗粒同时给予美沙拉嗪灌肠剂,保留灌肠;对照组给予口服柳氮磺胺毗啶。结果:临床疗效比较:治疗临床效果明显高于对照组(P<0.05)。结肠镜下黏膜组织改善情况明显高于对照组(P<0.05)。治疗组不良反应发生率明显低于对照组(P<0.01)。结论:美沙拉嗪口服联合灌肠治疗溃疡性结肠炎疗效确切,安全可靠。
Objective: To investigate the clinical efficacy and safety of mesalazine oral combined enema in the treatment of ulcerative colitis. Methods: Sixty patients with ulcerative colitis treated in our hospital from January 2006 to December 2010 were randomly divided into treatment group and control group. The treatment group was given oral mesalazine sustained-release granules simultaneously with mesalazine enema Agent, retention enema; control group given oral sulfasalazine. Results: The clinical curative effect comparison: The clinical effect of treatment is obviously higher than the control group (P <0.05). Colon mucosal tissue improvement was significantly higher than the control group (P <0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P <0.01). Conclusion: Mesalazine combined with oral enema for the treatment of ulcerative colitis is effective, safe and reliable.