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目的 :观察中药“肾衰方”治疗慢性肾功能衰竭的疗效。方法 :将 48例慢性肾衰患者分为基本情况接近的 2组。对照组 2 3例单纯采用西药开同、依那普利、水溶性类维生素、抗凝及饮食疗法等。治疗组 2 5例在上述基础上加用草药肾衰方。于治疗前后观察一般临床症状及血尿素氮、血肌酐、内生肌酐清除率变化。结果 :治疗组总有效率为 80 % ,高于对照组 5 2 1%(P <0 0 5 ) ,治疗后治疗组血尿素氮下降均数和内生肌酐清除率提高均数大于对照组 (t值分别为 3 0 6和 2 0 4,P均 <0 0 5 )。两组血肌酐差值均数间比较无显著性差异 (t=1 0 5 ,P >0 0 5 )。结论 :“肾衰方”能较明显增加尿氮及其它代谢废物排出 ,并有活血化瘀、抗凝、补钙等作用 ,能延缓慢性肾衰进展 ,疗效优于单纯西医非替代疗法。
Objective: To observe the curative effect of traditional Chinese medicine “Shenshuifang” in the treatment of chronic renal failure. Methods: 48 patients with chronic renal failure were divided into two groups with similar basic conditions. The control group of 23 cases of Western medicine alone with open, enalapril, water-soluble vitamins, anticoagulants and diet therapy. Treatment group 25 cases on the basis of herbal plus kidney decoction. Before and after treatment to observe the general clinical symptoms and blood urea nitrogen, serum creatinine, endogenous creatinine clearance rate changes. Results: The total effective rate of the treatment group was 80%, which was higher than that of the control group (P <0.05). After treatment, the mean decrease of blood urea nitrogen and endogenous creatinine clearance in the treatment group were greater than those in the control group t values were 3 0 6 and 2 0 4 respectively, P <0 05). There was no significant difference between the two groups in serum creatinine difference (t = 105, P> 0.05). Conclusion: “Decoction of Kidney Decoction” can significantly increase the excretion of urine nitrogen and other metabolic wastes, and has the functions of promoting blood circulation and removing blood stasis, anticoagulant and calcium supplement, and can delay the progress of chronic renal failure. The curative effect is superior to that of pure Western medical non-replacement therapy.