论文部分内容阅读
对海拔２２６０ｍ的西宁地区６００名不同年龄健康人进行了红细胞─—超氧化物歧化酶（ＳＯＤ）和过氧化脂质（ＩＰＯ）测定，并与平原同龄人的测值进行了对比分析。结果表明；①高原与平原居民均随着增龄而表现出ＳＯＤ活性降低，ＬＰＯ升高。②在各年龄组中，高原居民ＳＯＤ活性明显低于平原同龄人（Ｐ＜０．０１），而血清ＬＰＯ含量显著升高（Ｐ＜０．０１）。③与平原测值比较，随着增龄高原居民ＳＯＤ活性降更明显，ＬＰＯ升高的幅度也增加。上述改变表明了长期生活在低氧环境下的高原居民体内存在有自由基代谢失衡，这可能是高原人早衰的重要原因之一。
The erythrocyte superoxide dismutase (SOD) and lipid peroxidation (IPO) were measured in 600 healthy people of different ages in Xining, 2260m above sea level. The results were compared with that of plain peers. The results showed that: ①The plateau and plain inhabitants showed decreasing SOD activity and LPO increasing with age. ② In all age groups, SOD activity in plateau residents was significantly lower than that in plain peers (P <0.01), while serum LPO content was significantly increased (P <0.01). ③Compared with the plain measurement, as the SOD activity of aged people in highland age decreased significantly, the increase of LPO also increased. The above changes indicate that long-term living in hypoxia environment there is a free radical metabolism imbalance in the population, which may be one of the important causes of premature aging in the plateau.