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氯喹作为传统的老药，不仅用于抗疟疾治疗，还用于类风湿关节炎、红斑狼疮等疾病的治疗。近年发现氯喹还具有抗肿瘤作用，并在克服肿瘤耐药方面发挥重要作用。氯喹不仅通过抑制肿瘤的自噬增加放化疗的敏感性，还可抑制腺苷三磷酸结合体家族蛋白，减少抗肿瘤药物的排出；另外，氯喹还可通过影响DNA分子的稳定性、促进肿瘤血管正常化，同时提高蛋白酶体抑制剂效应、促进肿瘤免疫，进而达到抗肿瘤的作用。“,”Chloroquine as an old drug,is widely used as an anti-malarial agent and a useful agent for the treatment of rheumatoid arthritis and lupus erythematosus.In recent years,chloroquine has been studied for its potential as an enhancing agent in cancer therapies and plays a key role in reversing drug resistance .Chlo-roquine′s ability to block autophagy makes it as a potential chemotherapy and radiotherapy sensitizer . Besides,it can also inhibit ATP Binding Cassette family protein to decrease the discharge of anti-tumor drugs;it can also stabilize DNA,induce tumor vessel normalization,improve the effects of proteasome inhibi-tors and promote antitumor immunity,thus playing the anti-tumor role.