肝纤维化(Fibrosis) 长期给大鼠饲食米酒可导致肝胶原的堆积,这与过去认为乙醇具有刺激肝纤维化作用的观点相一致。长期以来存在的问题是到底哪些细胞或细胞群是造成纤维形成的原因。在初期培养的大鼠肝细胞也产生胶原,这可由乙醇抑制;可能是由于细胞内氧化还 Long-term feeding of rice wine to rats resulted in the accumulation of hepatic collagen, consistent with the notion that ethanol had the effect of stimulating hepatic fibrosis in the past. The long-standing problem is which cells or cell populations are the cause of fiber formation. Collagen is also produced in rat hepatocytes cultured initially, which can be inhibited by ethanol; probably due to intracellular oxidation