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目的 探讨孕妇血清总胆汁酸 (TBA)在正常妊娠过程中的变化。方法 用酶法检测孕妇血清中的TBA水平。结果 早孕、中孕和晚孕组的孕妇血清中TBA水平分别较非妊娠组升高 8.2 %、33.8%和 6 7.8% ,而且晚孕组比中孕组的孕妇血清中TBA水平也有明显升高。结论 血清TBA在妊娠过程中持续升高 ,孕妇在妊娠时就有潜在发生妊娠性肝内胆汁瘀积症 (ICP)的危险。
Objective To investigate the change of serum total bile acid (TBA) in pregnant women during normal pregnancy. Methods Enzymatic detection of serum TBA levels in pregnant women. Results The levels of TBA in serum of pregnant women in early pregnancy, middle-aged pregnant and late pregnancy groups increased by 8.2%, 33.8% and 6.88% respectively compared with those in non-pregnant group, and the levels of TBA in pregnant women of late pregnancy group were also significantly higher than those of pregnant women . Conclusions Serum TBA is continuously elevated during pregnancy. Pregnant women are at risk of developing pregnancy-induced intrahepatic cholestasis (ICP) during pregnancy.