论文部分内容阅读
目的 研究血浆内皮素 - 1(ET - 1)、一氧化氮 (NO)在心脏骤停缺血 再灌注损伤前后含量变化规律及意义。方法 取家兔 4 0只分别分为对照组、实验组 ,制作家兔心脏骤停缺血 再灌注模型 ,观察心肺复苏期各时点血浆ET - 1、NO、血压及心电变化。结果 动物在心脏骤停及复苏即刻血浆ET - 1含量未见升高 ,在心肺复苏 5分钟血浆ET - 1含量明显升高 (P <0 .0 5 ) ,而血浆NO水平降低 (P <0 .0 5 ) ,复苏后 0 .5小时血浆ET - 1明显升高(P <0 .0 1) ,复苏后 2小时血浆ET - 1、NO均较复苏前有明显上升 (P <0 .0 5 )。结论 在心脏骤停缺血 再灌注损伤过程中ET - 1、NO水平变化及相关关系可能是一种调节机制 ,并在病理生理过程中起重要作用。
Objective To study the changes of plasma endothelin - 1 (ET - 1) and nitric oxide (NO) contents before and after myocardial ischemia / reperfusion injury. Methods 40 rabbits were randomly divided into control group and experimental group. The models of myocardial ischemia - reperfusion in rabbits were made. The changes of plasma ET - 1, NO, blood pressure and ECG were observed at different time points. Results The plasma ET - 1 level did not increase immediately after cardiac arrest and resuscitation. The plasma ET - 1 level was significantly increased 5 minutes after cardiopulmonary resuscitation (P <0. 05), while the plasma NO level was decreased (P <0 0.05), plasma ET - 1 was significantly increased at 0. 5 hours after resuscitation (P <0. 01), plasma ET - 1 and NO at 2 hours after resuscitation were significantly higher than those before resuscitation (P <0. 0 5) 5). Conclusion The changes of ET - 1 and NO levels in cardiac arrest induced by ischemia / reperfusion injury may be a regulatory mechanism and play an important role in the pathophysiological process.