铜催化格氏试剂不对称1,4-、1,6-及1,2-共轭加成是构建手性碳的重要方法,其加成产物是许多天然产物以及手性药物合成的关键中间体.对铜催化的格氏试剂不对称1,4-、1,6-及1,2-共轭加成反应进行了较全面的综述,其中涉及的受体种类包括α,β-不饱和酮、不饱和酯、不饱和内酯、不饱和硫酯、不饱和醛和不饱和砜.此外,对不对称1,4-共轭加成反应的机理研究也进行了较详细的介绍. Copper-Catalyzed Grignard Reagents Asymmetric 1,4-, 1,6- and 1,2-conjugate additions are important ways to construct chiral carbons. Adducts are the key intermediate in the synthesis of many natural and chiral drugs A comprehensive review of the asymmetric 1,4-, 1,6- and 1,2-conjugate addition reactions of copper-catalysed Grignard reagents has been carried out, involving a wide range of α, β-unsaturated Ketones, unsaturated esters, unsaturated lactones, unsaturated thioesters, unsaturated aldehydes and unsaturated sulfones. In addition, the mechanism of the asymmetric 1,4-conjugate addition reaction has also been described in more detail.