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目的:通过对急性冠脉综合征(ACS)患者超敏C反应蛋白(Hs-CRP)和肌钙蛋白I(cTnI)的检测,探讨超敏C反应蛋白和cTnI的水平变化在ACS中的临床意义。方法:急性冠状动脉综合征患者共54例,其中急性心肌梗死(AMI)患者33例,不稳定型心绞痛(UAP)患者21例,对照组为稳定型心绞痛(SAP)患者30例,分别测定血清Hs-CRP和cTnI浓度,并进行比较。结果:(1)UAP、AMI组Hs-CRP、cTnI均显著高于SAP组(P<0.01);UAP组与AMI组比较,Hs-CRP、cTnI水平差异有显著性(P<0.01)。结论:(1)炎症在UAP、AMI的发展过程中起重要作用。(2)Hs-CRP、cTnI可作为判断急性冠状动脉综合征严重程度的独立有效指标(3)联合检测Hs-CRP、cTnI,对急性冠状动脉综合征的患者可以增加诊断和预后判断的力度。
OBJECTIVE: To investigate the changes of hypersensitive C-reactive protein and cTnI levels in patients with acute coronary syndrome (ACS) by detecting the levels of high-sensitivity C-reactive protein (Hs-CRP) and troponin I (cTnI) significance. Methods: A total of 54 patients with acute coronary syndrome were enrolled in this study. Among them, 33 cases were acute myocardial infarction (AMI), 21 cases were unstable angina pectoris (UAP) and 30 cases were stable angina pectoris (SAP) Hs-CRP and cTnI concentrations, and compared. Results: (1) The Hs-CRP and cTnI in UAP and AMI groups were significantly higher than those in SAP group (P <0.01). The levels of Hs-CRP and cTnI in UAP group and AMI group were significantly different (P <0.01). Conclusion: (1) Inflammation plays an important role in the development of UAP and AMI. (2) Hs-CRP and cTnI can be used as independent effective indicators for judging the severity of acute coronary syndrome. (3) The combined detection of Hs-CRP and cTnI can increase the diagnosis and prognosis of patients with acute coronary syndrome.