随着人类基因组计划的完成、基因功能的发现,以及各种高通量筛选方法的实现,药物靶标已经成为现代创新药物研发的一个重要环节。尽管如此,药物靶标的创新速率仍然维持在非常低的水平上,每年成功上市药物的分子靶标仅有3~5个是新靶标。分析国外药物靶标的开发特点和内在规律,可以为我国生物制药公司和研发机构选择合适的药物靶标提供一些有用的信息。 With the completion of the human genome project, the discovery of gene function, and the realization of various high-throughput screening methods, drug targets have become an important link in the development of modern innovative drugs. In spite of this, the innovation rate of drug targets is still kept at a very low level. Only 3 to 5 of the molecular targets of drugs marketed successfully each year are new targets. Analysis of the development characteristics and inherent laws of foreign drug targets can provide some useful information for our country’s biopharmaceutical companies and R & D institutions to choose suitable drug targets.