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对免疫性血小板减少性紫癜(ITP)的治疗,已有可供选择的方案,但有时治疗可能无效,并且严重时可出现危及生命的并发症。作者报告3例用常规治疗无效,依据α-干扰素可词整与自身免疫过程有关的效应器 B 细胞群,故采用α-干扰素治疗。病例 36岁妇女,有 ITP 体征和症状,血小板数2×100~9/L。骨髓穿刺检查显示有丰富的巨核细胞。血小板或巨核细胞检测没有发现与血小板相关的 IgG。以前曾用强的松龙、氨苯砜、长春新碱、脾切除等治疗,效果不著,病人对苯丁酸氮芥有轻微的疗效,提
There are alternatives available for the treatment of idiopathic thrombocytopenic purpura (ITP), but sometimes treatment may be ineffective and life-threatening complications may occur in severe cases. The authors report 3 cases of conventional treatment is invalid, according to the word α-interferon and autoimmune processes related effector B cell population, so the use of α-interferon treatment. A 36-year-old woman with ITP signs and symptoms and 2 × 100 ~ 9 / L platelets. Bone marrow aspiration tests showed abundant megakaryocytes. No detectable platelet-associated IgG was detected in platelets or megakaryocytes. Had previously used prednisolone, dapsone, vincristine, splenectomy and other treatment, the effect is not with the patient chlorambucil have a slight effect, mention