联合核基质蛋白22与膀胱肿瘤抗原检测用于监测膀胱肿瘤的复发

来源 :中华医学杂志 | 被引量 : 0次 | 上传用户:youjia88
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目的探讨一种无创,快速,高效便捷的监测膀胱肿瘤复发的方法用于肿瘤术后的随访.方法采用标准ELISA 法检测病人尿中的核基质蛋白22(NMP-22)值,并对患者进行尿液膀胱肿瘤抗原(BTA stat)测定, 膀胱镜检及病理检测以明确有无肿瘤复发.结果与膀胱镜检及活检结果相比较,尿的NMP-22检测可发现76.7% (33/43) 复发的病例,尿的BTA stat可发现67.4% (29/43)复发的病例.若将两项检测的结果综合考虑,则检测的准确率达93.0% (40/43).结论尿的NMP-22检测为一种快速,高效,便捷的监测膀胱肿瘤复发的方法,若同BTA Stat检测联合使用,会提高其准确率,并可在术后随访中减低膀胱镜检的频率.
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