头孢唑啉为一种广谱半合成抗菌素 ,临床上广为使用 ,但在肾功能不全时 ,如不减量 ,可导致严重的中枢神经系统副作用 ,我们遇到 6例尿毒症患者使用常规剂量的头孢唑啉后 ,发生了急性可逆性脑病 ,现报告如下 ,以引起同道的高度重视。1　病例报告　　典型病例 1,女 ,36岁。因慢性 Cefazolin is a broad-spectrum semi-synthetic antibiotics, widely used clinically, but in renal insufficiency, such as not reducing, can lead to serious central nervous system side effects, we encountered 6 cases of uremic patients using conventional dose Of cefazolin, the occurrence of acute reversible encephalopathy, are reported as follows, in order to arouse the attention of fellow. A case report of a typical case 1, female, 36 years old. Because of chronic