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目的通过检测睡眠呼吸暂停综合征患者（ＳＡＳ）血清中一氧化氮（ＮＯ）的含量，预测其与ＳＡＳ患者多系统器官损害的关系。方法用ＮＯ３／ＮＯ２法测定ＳＡＳ有并发症组（Ⅰ组）、ＳＡＳ无并发症组（Ⅱ组）及对照组（Ⅲ组）睡前及醒后血清中的ＮＯ含量。结果Ⅰ组患者睡前血清中ＮＯ含量与其它两组相比无显著差异（Ｐ＞００５）；睡醒后Ⅰ组与Ⅱ、Ⅲ组相比ＮＯ含量明显增高（Ｐ＜００１及Ｐ＜００５）。结论ＮＯ是ＳＡＳ患者发生各系统严重并发症的重要信息物质之一，它的生成过量将导致ＳＡＳ患者明显的多系统器官损害。
OBJECTIVE: To detect the level of nitric oxide (NO) in the serum of patients with sleep apnea syndrome (SAS) and predict its relationship with multisystem organ damage in patients with SAS. Methods The levels of NO in serum before and after SAS complication (group Ⅰ), SAS noncomplication group (group Ⅱ) and control group (group Ⅲ) were determined by NO3 / NO2 method. Results Compared with the other two groups, there was no significant difference in NO level before going to sleep between the two groups (P> 005), and the content of NO in group Ⅰ was significantly higher than that in group Ⅱ and Ⅲ P <005). Conclusions NO is one of the most important informational substances in SAS patients with severe systemic complications. Overproduction of NO may lead to obvious multisystem organ damage in SAS patients.