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目的：探讨氟伐他汀对肾病综合征高脂血症的疗效及其副作用和对肝、肾功能的影响。方法：检测住院患者６０ 例应用氟伐他汀为治疗组，４０ 例应用藻酸双脂钠为对照组，治疗时间为６ 周。两组治疗前后均查总胆固醇、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、肌酐、尿素氮及转氨酶，采用ｔ检验。结果：治疗组应用氟伐他汀（４０ｍ ｇ／ｄ）后可显著降低高胆固醇及混合性高脂血症，与对照组相比，Ｐ＜ ０．０１。结论：氟伐他汀对肾病高脂血症确有降低作用。
Objective: To investigate the curative effect of fluvastatin on nephrotic syndrome with hyperlipidemia and its side effects and its effects on liver and kidney function. Methods: Sixty patients were treated with fluvastatin as the treatment group and 40 patients with alginic acid as control group. The treatment time was 6 weeks. Total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, creatinine, urea nitrogen and aminotransferase were detected before and after treatment in both groups. The t test was used. Results: Treatment with fluvastatin (40 mg / d) significantly reduced hypercholesterolemia and hypercholesterolemia, P <0.01 compared with the control group. Conclusion: Fluvastatin has a definite effect on nephropathy of hyperlipidemia.