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为了确定维生素C对正常人NO_2诱发的气道高反应性的作用,作者进行了双盲随机的研究。11名正常人按随机指定比顺序作4次暴露。每次暴露先服维生素C(200mg每日4次,连服三日)或服安慰剂,然后或暴露于清洁的空气或暴露于2.0ppm的NO_2气溶胶。每次暴露前后测肺功能,暴露前测血维生素C含量,暴露后测气道反应性。服安慰剂后暴露NO_2引起气道反应性显著增高(空气-安慰剂64±7,而NO_2-安慰剂53±8 mg/ml)。服维生素C显著地抑制了气道反应性的变化(65±13mg/ml,p<0.04)。这些
To determine the effect of vitamin C on NO 2 -induced airway hyperresponsiveness, we conducted a double-blind, randomized study. Eleven normal individuals were randomly assigned 4 exposures in order of preference. Vitamin C (200 mg daily for 3 days) or placebo was administered with each exposure and then either exposed to clean air or to 2.0 ppm NO 2 aerosol. Lung function was measured before and after each exposure, blood levels of vitamin C before exposure and airway responsiveness after exposure. Post-placebo exposure of NO 2 induced a significant increase in airway responsiveness (air-placebo 64 ± 7 vs. NO ± placebo 53 ± 8 mg / ml). Administration of vitamin C significantly suppressed changes in airway responsiveness (65 ± 13 mg / ml, p <0.04). These ones