论文部分内容阅读
目的:探索结直肠腺癌中Caveolin-1和微淋巴管密度(lymphatic microvessel density,LMVD)的关系及其与肿瘤临床病理特征和预后的关联。方法:运用免疫组织化学法测定90例结直肠腺癌和45例正常结直肠组织中Caveolin-1的表达,并以D2-40为标记物,测定结直肠腺癌组织的LMVD,分析Caveolin-1和LMVD与临床病理参数之间的关联。结果:结直肠腺癌中Caveolin-1蛋白的阳性表达率(73.33%)明显高于正常结直肠组织(11.11%,P<0.01);结直肠腺癌中的LMVD值(18.25±2.36)明显高于正常结直肠组织(3.14±1.58,P<0.01);Caveolin-1表达程度和LMVD与肝转移、肿瘤浸润深度、淋巴结转移和TNM分期具有相关性(P<0.01);Caveolin-1表达阴性组的LMVD值明显低于阳性组(P<0.01);结论:Caveolin-1在结直肠癌中的表达与微淋巴管生成密切相关,其表达和LMVD是结直肠癌患者的独立预后指标。
Objective: To explore the relationship between Caveolin-1 and lymphatic microvessel density (LMVD) in colorectal adenocarcinoma and its relationship with clinicopathological features and prognosis. Methods: The expression of Caveolin-1 in 90 cases of colorectal adenocarcinoma and 45 cases of normal colorectal tissue was detected by immunohistochemical method. The LMVD of colorectal adenocarcinoma was determined by D2-40 as a marker. The expressions of Caveolin-1 And the correlation between LMVD and clinicopathological parameters. Results: The positive expression rate of Caveolin-1 in colorectal adenocarcinoma was significantly higher than that in normal colorectal tissue (11.11%, P <0.01). The LMVD in colorectal adenocarcinoma (18.25 ± 2.36) was significantly higher (3.14 ± 1.58, P <0.01). The expression of Caveolin-1 and the correlation between LMVD and liver metastasis, depth of tumor invasion, lymph node metastasis and TNM stage (P <0.01) (P <0.01). Conclusions: The expression of Caveolin-1 in colorectal cancer is closely related to lymphangiogenesis, and its expression and LMVD are independent prognostic factors in patients with colorectal cancer.