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目的观察双歧杆菌对抗生素诱导的菌群失调大鼠血清一氧化氮(Nitricoxlcle,NO)及一氧化氮合成酶(Nitric oxide synthase,NOS)的影响。方法肠道盐酸林可霉素脱污染制备肠道菌群失调大鼠。造模成功后用双歧杆菌活菌灌胃治疗,14 d后血清学检测细胞因子NO、NOS水平。结果与模型组相比,NO含量明显增多(P<0.05);NOS含量降低(P<0.05)。结论双歧杆菌活菌可能通过调节细胞因子NO、NOS含量而调整菌群失调大鼠肠道内有益菌的比例。
Objective To observe the effects of Bifidobacterium on the levels of nitric oxide (NO) and nitric oxide synthase (NOS) in antibiotic-induced flora in rats. Methods Intestinal lincomycin hydrochloride was decontaminated to prepare gut flora. Bifidobacterium was inoculated intraperitoneally after the model was successfully established. Serum levels of NO and NOS were detected 14 days later. Results Compared with model group, NO content increased significantly (P <0.05) and NOS content decreased (P <0.05). Conclusion Bifidobacterium viable bacteria may regulate the proportion of beneficial bacteria in the intestine of rats with dysbacteriosis by regulating the content of cytokines NO and NOS.