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回顾1980年以来有关铅中毒的诊断和治疗方面虽然没有突破性的进展,但认识有所深入,主要有以下几方面: 一、关于诊断方面 1.铅中毒时游离原卟啉在红细胞内并非“游离”的,而是与锌离子结合成锌原卟啉(ZPP),干扰原卟啉与铁结合。用萤光法测定ZPP目前已成为诊断铅生毒的有力手段之一,它是根据ZPP具有特定的荧光谱,在一定波长的荧光下显示出特有的荧光峰,与固定的荧光片比较,通过电脑系统显示出ZPP的含量。正常值在100μg/100ml血以下,与血铅呈平行关系,国内薛氏提出用ZPP诊断铅
Review of the diagnosis and treatment of lead poisoning since 1980, although no breakthrough progress, but some understanding of the depth, mainly in the following aspects: First, the diagnosis 1. Lead poisoning free protoporphyrin in the red blood cells is not “ Free ”, but combined with zinc ions into zinc protoporphyrin (ZPP), interfering protoporphyrin and iron binding. Fluorescence determination of ZPP has now become a powerful tool for the diagnosis of lead poisoning, which is based on the ZPP has a specific fluorescence spectrum, fluorescence at a certain wavelength shows a unique fluorescence peak, compared with the fixed fluorescence, by The computer system shows the ZPP content. The normal value of 100μg / 100ml blood below the blood lead was paralleled, the domestic Xue’s proposed ZPP diagnosis of lead