核因子κB(NF-κB)是一类重要的转录调节因子,在体内外多种因素的刺激与激活后,可转移到核内参与调节多种基因的转录表达,从而参与广泛的生物学效应。研究发现NF-κB与恶性血液肿瘤的发生、发展、预后及化疗的耐受有关。了解NF-κB的生物学功能及其与恶性血液病的关系,选择性地调控其生物学活性,可能为恶性血液病的治疗提供一个新的途径。 Nuclear factor κB (NF-κB) is an important class of transcriptional regulators. After stimulated and activated by many factors both in vitro and in vivo, NF-κB may be transferred to the nucleus to regulate the transcriptional expression of multiple genes and thus participate in a wide range of biological effects . The study found that NF-κB and malignant hematological malignancy, development, prognosis and chemotherapy tolerance. To understand the biological function of NF-κB and its relationship with hematologic malignancies, the selective regulation of its biological activity may provide a new approach for the treatment of hematologic malignancies.