局限性硬皮病病因不清,到目前为止尚无理想的治疗药物。物理疗法和外科治疗仅对硬化的纤维组织引起的活动受限有部分改善。 报告1例应用抗过敏药物肉桂氨茴酸(tranilast)治疗取得较好疗效。该病人男性,14岁,自1989年6月右下肢皮肤和皮下组织进行性发硬和变薄,活动受限和挛缩。物理检查:见右小腿条状浅黄色蜡状硬化皮疹。右侧第2、3趾的跖趾关节背侧活动度为20°,右小腿缩短。实验室检查:血、尿常规、心电图及X线结果均正常。血清蛋白电泳在正常范围。血清IgE Limitations Scleroderma etiology, so far there is no ideal therapeutic drug. Physiotherapy and surgical treatment have only partially improved the activity limitation caused by hardened fibrous tissue. Report of 1 case of anti-allergy drug cinnamic anthranilic acid (tranilast) treatment achieved better results. The patient, male, 14 years old, developed stiff and thinning of the right lower extremity skin and subcutaneous tissue since June 1989, with limited mobility and contracture. Physical examination: See the right leg strip light yellow waxy sclerosis. Right and left third toe metatarsophalangeal joint dorsal movement of 20 degrees, right lower leg shortening. Laboratory tests: blood, urine, ECG and X-ray results were normal. Serum protein electrophoresis in the normal range. Serum IgE