绪言抗生素治疗中,腹泻为较常见的并发症。临床及解剖所见可自轻度自限性稀便以至严重危及生命的结肠炎。近来研究确认顽固梭状芽胞杆菌(Clostridiu Dif-ficile)为本并发症的重要原因。本菌产生致细胞病变毒素(Cytopathic Toxin),可用组织培养而测得。顽固梭状芽胞杆菌所致的腹泻或结肠炎患者常对口服应用万古霉素以直接抗菌或应用消胆胺以结合毒素均具良好效应。本文目的在于复习因 Introduction In the treatment of antibiotics, diarrhea is the most common complication. Clinical and anatomical findings can be mild self-limiting loose stools as well as serious life-threatening colitis. Recent studies have confirmed that Clostridium Dif-ficile is an important cause of this complication. This bacterium produces Cytopathic Toxin, which can be measured by tissue culture. Clostridium occidentalis caused by diarrhea or colitis patients often oral administration of vancomycin in order to direct antibacterial or cholestyramine to bind toxins have a good effect. The purpose of this article is to review the cause