论文部分内容阅读
目的 探讨有关因素在先天性泌尿生殖系统结构畸形发病中的作用。方法 采用成组匹配的病例对照研究方法 ,对 95例患先天性泌尿生殖系统畸形的围产儿和 16 0例对照围产儿及其父母的情况进行调查。采用非条件logistic回归模型进行多因素分析 ,计算OR值及OR的 95 %可信限。结果 先天性泌尿生殖系统结构畸形多发生于男性围产儿 (性别构成比为 74.7% ,χ2 =74.86 3,P =0 .0 0 1)。多元逐步回归分析表明 :母亲孕早、中期感冒 (OR =7.0 34 ,95 %CI =3.488～ 14.187)、低出生体重 (OR =4.0 75 ,95 %CI =1.774～ 9.36 2 )、孕次≥ 2 (OR =3.133,95 %CI =1.5 14～ 6 .483)及母亲孕前职业性接触有害化学物质 (OR =10 .496 ,95 %CI=1.0 5 3～ 10 4.6 5 1)为先天性泌尿生殖系统结构畸形的危险因素。结论 胎儿男性性别 ,母亲孕早、中期感冒 ,低出生体重 ,母亲孕次≥ 2及孕前职业性接触有害化学物质与胎儿发生先天性泌尿生殖系统畸形有关联
Objective To explore the role of related factors in the pathogenesis of structural abnormalities of genitourinary system. Methods A group matched matched case-control study was conducted to investigate 95 cases of perinatal children with congenital urogenital malformations and 160 control perinatal children and their parents. Multivariate analysis was performed using a non-conditional logistic regression model to calculate the OR value and the 95% confidence limit for OR. Results The structural abnormalities of the genitourinary system mostly occurred in male perinatals (sex ratio was 74.7%, χ2 = 74.86 3, P = 0.010). Multivariate stepwise regression analysis showed that the mothers had lower body weight (OR = 4.075, 95% CI = 1.774-9.36 2), pregnancy ≥ 2 (OR = 7.034, 95% CI = 3.488-14.187) (OR = 3.133, 95% CI = 1.514 ~ 6.483) and mother’s pre-pregnancy occupational exposure to harmful chemicals (OR = 10.4949, 95% CI = 1.05 3 ~ 10 4.6 5 1) for the genitourinary tract System structural deformity risk factors. Conclusions Fetal male gender, maternal pregnancy early, mid-cold, low birth weight, mothers pregnancy ≥ 2 and pre-pregnancy occupational exposure to harmful chemicals and fetal congenital urogenital malformations associated