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中枢神经系统为弓形虫最常侵犯的器官,我们调查了132例以中枢神经系统疾病就诊的患儿弓形虫感染情况。132例患儿中弓形虫抗体阳性者41例,总阳性为31.06％,其中小儿急性偏瘫、脑炎、癫痫的阳性率分别为37.04％、35％、32.14％。小儿急性偏瘫为突然发生的偏瘫并进行性加重,右侧多于左侧。瘫痪多在起病3～5天达高峰,肌力多在Ⅰ～Ⅳ级,腱反射亢进,无惊厥,神志清楚但有不同程度的智力障碍、失语、流涎。脑脊液正常,脑电图中度以上损害,CT示占位性病变或炎症改变。有2例患儿脑脊液及血液中均找到弓形虫滋养体,小白鼠接种成功。
Central nervous system Toxoplasma gondii most frequently violated organs, we investigated the 132 cases of central nervous system disease in children with Toxoplasma infection. Among 132 cases of Toxoplasma gondii antibody positive in 41 cases, the total positive was 31.06%. The positive rates of acute hemiplegia, encephalitis and epilepsy in children were 37.04%, 35% and 32.14% respectively. Acute hemiplegia in children with sudden hemiplegia and progressive increase in the right than the left. Paralysis and more in the onset of 3 to 5 days peak, more muscle strength in grade Ⅰ ~ Ⅳ, tendon hyperreflexia, no convulsions, conscious but with varying degrees of mental retardation, aphasia, salivation. Normal cerebrospinal fluid, moderate or more damage to the EEG, CT showed occupying lesions or inflammatory changes. Toxoplasma trophozoites were found in 2 patients with cerebrospinal fluid and blood, mice were vaccinated successfully.