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Stat3是转录信号转导子与激活子家族STATs的重要成员,广泛表达于不同类型的细胞和组织中,介导多种细胞因子和生长因子的信号向细胞核转导,影响众多靶基因的转录,Stat3持续激活可导致细胞异常增殖和恶性转化,目前已被公认为癌基因。本文就Stat3的结构及其在肿瘤发生、发展和基因治疗中的进展作一综述。
Stat3 is an important member of transcription signal transducer and activator subfamily STATs. It is widely expressed in different types of cells and tissues. Stat3 mediates the signal transduction of many cytokines and growth factors to the nucleus and affects the transcription of many target genes. Continuous activation of Stat3 can lead to abnormal cell proliferation and malignant transformation, has now been recognized as oncogene. This article reviews the structure of Stat3 and its progress in tumorigenesis, development and gene therapy.