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本文报道了活血Ⅱ号与心房肽Ⅲ对血管平滑肌的效应。当在浴槽中加入3×10~(-8)M 的心房肽Ⅲ时,可使处在高张力状态的离体主动脉条产生强而持久的松弛效应。加入相当200mg 生药的活血Ⅱ号仅能使动脉条产生一过性轻度的舒张,如和心房肽Ⅲ合并使用则效果明显增强。实验结果表明人工合成的心房肽Ⅲ是一种有效的血管平滑肌松弛剂,活血Ⅱ号和心房肽Ⅲ可能有协同作用。
This article reports the effect of Huoxue II and atrial peptide III on vascular smooth muscle. When 3×10 −8 M of atrial peptide III was added to the bath, a strong and long-lasting relaxation effect could be produced in the ex vivo aortic strips under high tension. The addition of 200 mg crude drug Huoxue No. II can only produce transient and mild relaxation of the arterial bar. If combined with atrial peptide III, the effect is significantly enhanced. The experimental results show that the synthetic atrial peptide III is a potent vascular smooth muscle relaxant, and Huoxue II and atrial peptide III may have a synergistic effect.