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目的:探讨绝经期女性血脂及血压与糖尿病骨质疏松发生的关系。方法:选取2014年3月-2015年5月在我院接受治疗的绝经期女性糖尿病患者100例作为研究对象,根据骨密度不同将患者分为骨质疏松组和非骨质疏松组。检测并比较两组研究对象的血脂及血压水平,分析其与骨质疏松发生的关系。结果:骨质疏松组患者总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平均高于非骨质疏松组,差异具有统计学意义(P<0.05);与非骨质疏松组比较,骨质疏松组患者舒张压(DBP)升高,而收缩压(SBP)降低,差异具有统计学意义(P<0.05);Pearson相关性分析结果显示,年龄、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)与双股骨骨密度呈正相关关系(P<0.05),与腰椎骨密度呈负相关关系(P<0.05);Logistic回归分析结果显示,年龄、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及收缩压(SBP)是糖尿病骨质疏松发生的危险因素(P<0.05)。结论:绝经期女性糖尿病患者的年龄、总胆固醇、LDL-C及收缩压与骨质疏松密切相关,临床应给予重视并采取有效措施进行预防。
Objective: To investigate the relationship between blood lipids and the development of diabetes and osteoporosis in postmenopausal women. Methods: A total of 100 cases of postmenopausal women with diabetes mellitus treated in our hospital from March 2014 to May 2015 were selected as study objects. Patients were divided into osteoporosis group and non-osteoporosis group according to different BMD. The levels of blood lipids and blood pressure in both groups were detected and compared, and their relationship with osteoporosis was analyzed. Results: The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in osteoporosis group were significantly higher than those in non-osteoporosis group (P <0.05). Compared with the non-osteoporosis group, diastolic blood pressure (DBP) and systolic blood pressure (SBP) were decreased in the osteoporosis group (P <0.05), and the difference was statistically significant ). Pearson correlation analysis showed that there was a positive correlation between age, total cholesterol (TC) and LDL-C and double femur BMD (P <0.05), but negatively correlated with BMD P <0.05). Logistic regression analysis showed that age, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) were the risk factors of diabetic osteoporosis (P <0.05). Conclusion: Age, total cholesterol, LDL-C and systolic blood pressure are closely related to osteoporosis in menopausal women with diabetes, and clinical attention should be given and effective measures should be taken to prevent it.