Background Septal Surfing Technology(SST) is one of the most important techniques for collateral channels(CCs) crossing in retrograde chronic total occlusion(CTO) of percutaneous coronary intervention(PCI). We examined this technique’s usefulness in retrograde CTO-PCI cases. Methods We retrospective analyzed 728 consecutive CTO-PCI cases from January 2014 to September 2016. One hundred and forty-two patients who had undergone retrograde PCIs using septal collateral channels(CCs) were collected. Univariate and multivariate analyses were conducted to identify independent predictors for SST CCs crossing success. Results The CCs crossing success rate was 89.4% during retrograde PCI. Three factors were figured out as independent predictors, including CCs tortuosity(OR 0.164, 95%CI:0.041-0.657; P=0.011), diameter of distal CTO lesion(2.035, 95%CI:1.011-4.099; P=0.047) and LAD-CTO(OR 0.244, 95%CI:0.067-0.894; P=0.033). There were complications of CCs injury in 23.2% cases and 2.1% cases had cardiac tamponade without any in-hospital death. Conclusion SST is an effective method in collateral crossing during retrograde CTO-PCI. It has high successful rate regardless of the Werner Collateral Class of interventional collaterals, especially in invisible collaterals. This technology is feasible in daily practice of retrograde PCI. Background Septal Surfing Technology (SST) is one of the most important techniques for collateral channels (CCs) crossing in retrograde chronic total occlusion (CTO) of percutaneous coronary intervention (PCI). We examined this technique’s usefulness in retrograde CTO-PCI cases. Methods We retrospective analyzed 728 consecutive CTO-PCI cases from January 2014 to September 2016. One hundred and forty-two patients who had undergone retrograde PCIs using septal collateral channels (CCs) were collected. Univariate and multivariate analyzes conducted conducted to identify independent predictors for SST CCs crossing success. Results The CCs crossing success rate was 89.4% during retrograde PCI. Three factors were figured out as independent predictors, including CCs tortuosity (OR 0.164, 95% CI: 0.041-0.657; P = 0.011), diameter of distal CTO There were complications of CCs injury in 23.2% of cases and 2.1% of patients with lesion (2.035, 95% CI: 1.011-4.099; P = 0.047) and LAD-CTO (OR 0.244, 95% CI: 0.067-0.894; cases had c It has high successful rate regardless of the Werner Collateral Class of interventional collaterals, especially in invisible collaterals. This technology is feasible in daily practice of retrograde PCI.