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目的:观察腹腔镜手术联合短效口服避孕药治疗子宫内膜异位症(Endometriosis,EMS)的临床疗效。方法:选取2013年1月~2015年8月我院收治腹腔镜术后经组织病检证实的EMS患者100例,将其随机分为短效口服避孕药组(50例)和对照组(50例)。短效口服避孕药组患者术后月经第三天开始口服去氧孕烯炔雌醇片,每日一片,连续6个周期,对照组不给予任何相关治疗措施。所有患者均随访12个月,比较两组患者的症状缓解率、复发率及术后一年妊娠率,并观察治疗组患者的不良反应情况。结果:短效口服避孕药组症状有效率为92%,复发率为6%,术后一年妊娠率为36%,在症状缓解、控制复发及提高术后妊娠几率方面均显著高于对照组(56%、46%、4%)。治疗组不良反应主要为潮热、多汗等更年期样症状,通过反加治疗后均缓解。结论:腹腔镜联合短效口服避孕药组治疗EMS,可有效缓解症状,降低复发率,提高术后一年妊娠率,且无严重药物不良反应,值得临床推广应用。
Objective: To observe the clinical efficacy of laparoscopic surgery combined with short-acting oral contraceptives in the treatment of endometriosis (EMS). Methods: One hundred patients with EMS confirmed by histopathology after laparoscopic surgery in our hospital from January 2013 to August 2015 were randomly divided into short-term oral contraceptive group (50 cases) and control group (50 cases) example). Short-acting oral contraceptives group patients after oral administration of oral administration of desogestrel ethinyl estradiol tablets one day, six consecutive cycles, the control group did not give any relevant treatment. All patients were followed up for 12 months. The rate of symptom relief, relapse rate and one-year pregnancy rate were compared between the two groups. The adverse reactions in the treatment group were also observed. Results: The short-acting oral contraceptives effective rate was 92%, the recurrence rate was 6%, one year after the pregnancy rate was 36%, in symptom relief, control recurrence and improve the probability of postoperative pregnancy were significantly higher than the control group (56%, 46%, 4%). Adverse reactions in the treatment group were mainly menopausal symptoms such as hot flashes and hyperhidrosis, and were relieved after anti-addiction treatment. Conclusion: Laparoscopy combined with short-acting oral contraceptives in the treatment of EMS, which can effectively relieve symptoms, reduce the recurrence rate, improve pregnancy rate after one year, and no serious adverse drug reactions, it is worthy of clinical application.