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【目的】探讨早期抚触联合高压氧疗、水疗对重度新生儿缺氧缺血性脑病（HIE）近期神经运动功能的影响。【方法】收集 H IE患儿497例，按照治疗方法分为A、B、C三组，A组采用单纯早期抚触，B组抚触联合高压氧疗，C组采用抚触联合水疗。对比三组患儿运动功能、神经20项评分标准（NBNA ）评分及治疗后体质量、身高、每日摄奶量情况。【结果】治疗后A组完成Ⅲ级动作比例明显低于B组和C组（ P ＜0．05），其中B组与C组相比差异无统计学意义（ P＞0．05）；治疗2周、4周后B组、C组NBNA评分显著高于A组（ P＜0．05），其中B、C两组间相比NBNA评分差异无统计学意义（ P ＞0．05）；治疗4周后B组、C组患儿体质量、身高、每日摄奶量均显著优于A组（P ＜0．05），B、C组两两相比差异无统计学意义（P ＞0．05）。【结论】早期抚触联合高压氧或水疗均可以促进HIE患儿神经运动功能的康复，有利于新生儿的生长、发育，值得临床推广应用。“,”To explore the effect of early massage combined hyperbaric oxygen therapy ,hydro-therapy on recent nerve motor function of severe neonatal hypoxic-ischemic encephalopathy(HIE) .[Methods]Totally 497 patients with HIE were collected .According to the treatment methods ,all patients were divided into group A ,B and C .Group A received simple early massage ,and group B received massage combined with hyperbaric oxygen therapy ,and group C received massage combined with hydrotherapy .Motor function ,nerve 20-item score criteria(NBNA) score ,body weight ,height ,daily milk intake after treatment were compared a-mong 3 groups .[Results]After treatment ,the proportion of taking grade Ⅲ action in group A was obviously lower than that in group B and group C( P 0 .05) .NBNA scores in group B and group C at 2 and 4 weeks after treatment were signifi-cantly higher than those in group A ( P 0 .05) .The weight ,height and daily milk intake in group B and group C at 4 weeks after treatment were significantly better than group A ( P 0 .05) .[Conclusion]Early massage combined with hyperbaric oxygen or hydrotherapy can promote neural motor function rehabilitation in pediatric patients with HIE and is condu-cive to neonatal growth and development .Therefore ,it is worthy of clinical promotion .