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目的探讨腺苷蛋氨酸治疗急性药物性肝损伤的临床疗效。方法选取2012—2015年莱州市人民医院收治的急性药物性肝损伤患者40例。随机将患者分成试验组与对照组,各20例。对照组患者给予5%葡萄糖溶液+门冬氨酸钾镁静脉滴注,试验组患者在对照组基础上加用5%葡萄糖溶液+腺苷蛋氨酸静脉滴注。比较两组患者治疗前及治疗2、4周临床疗效、肝功能改善情况及不良反应发生情况。结果治疗2、4周试验组患者肝功能改善总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生严重不良反应。结论腺苷蛋氨酸治疗急性药物性肝损伤的临床疗效确切,可有效改善患者肝功能,且不良反应少。
Objective To investigate the clinical efficacy of adenosine methionine in the treatment of acute drug-induced liver injury. Methods Forty patients with acute drug-induced liver injury admitted in Laizhou People’s Hospital from 2012 to 2015 were selected. Patients were randomly divided into experimental group and control group, 20 cases each. Patients in the control group were given 5% dextrose solution plus potassium and magnesium aspartate intravenously, and patients in the test group were intravenously dripped with 5% glucose solution and adenosylmethionine on the basis of the control group. The clinical efficacy, improvement of liver function and incidence of adverse reactions before and 2 and 4 weeks of treatment were compared between the two groups. Results The total effective rate of liver function improvement in the experimental group at 2 and 4 weeks after treatment was significantly higher than that of the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Adenosine methionine treatment of acute drug-induced liver injury clinical curative effect, can effectively improve liver function in patients with less adverse reactions.