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生长分化因子-9是重要的卵母细胞源性生长因子。其在促进卵母细胞生长与分化以及颗粒细胞增殖、卵丘膨胀、抑制颗粒细胞和卵泡膜细胞分化的过程中起重要作用。卵巢早衰是病因不清又无有效治疗手段的复杂疾病。研究认为,卵巢内始基卵泡形成数目的减少、已形成的卵泡闭锁速度加快和对促性腺激素刺激不敏感是造成卵巢早衰的主要病因。生长分化因子-9参与了这一过程。
Growth-differentiation factor-9 is an important oocyte-derived growth factor. It plays an important role in promoting oocyte growth and differentiation as well as granulosa cell proliferation, cumulus expansion and inhibiting the differentiation of granulosa cells and theca cells. Premature ovarian failure is a complex disease with unclear etiology and no effective treatment. Studies suggest that the reduction in the number of primordial follicles in the ovary, the formation of follicles at an accelerated rate and insensitivity to gonadotropin stimulation is the leading cause of premature ovarian failure. Growth Differentiation Factor-9 is involved in this process.