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本文总结我院１９９３年６月～１９９４年７月从临床标本中分离的１７２株金黄色葡萄球菌（金葡菌），１３４株（７７．９％）为耐甲氧西林金葡菌（ＭＲＳＡ），其中８０．６％（１０８／１３４）为医院染株。１３３株（９９．３％）ＭＲＳＡ对林可霉素、青霉素Ｇ耐药；对红霉素、庆大霉素的耐药率亦高达９７％；第一代头孢菌素对ＭＲＳＡ的抑菌作用明显下降，头孢唑啉的抑菌率仅为７．５％，ＭＩＣ５０＞１６ｍｇ／Ｌ；环丙沙星耐药率上升迅速，对ＭＲＳＡ的耐药率达８６．６％，ＭＴＣ５０＞４ｍｇ／Ｌ。ＭＲＳＡ的多重耐药性十分明显，９６．３％（１３０／１３４）对５种以上抗菌药物耐药。甲氧西林对敏感金葡菌耐药率较低。万古霉素对ＭＲＳＡ仍具良好的抗菌活性，抑菌率１００％，ＭＩＣ５０为２．２８ｍｇ／Ｌ，ＭＩＣ９０为４．６３ｍｇ／Ｌ。
This article summarizes 172 strains of Staphylococcus aureus (Staphylococcus aureus) isolated from clinical specimens from June 1993 to July 1994 in our hospital, and 134 (77.9%) strains are MRSA (methicillin-resistant Staphylococcus aureus) , Of which 80.6% (108/134) were hospital dyed strains. 133 strains (99.3%) of MRSA were resistant to lincomycin and penicillin G; the resistance rate to erythromycin and gentamicin was as high as 97%; the antibacterial activity of the first generation cephalosporins against MRSA The antibacterial rate of cefazolin was only 7.5%, the MIC50> 16mg / L; the rate of resistance to ciprofloxacin rose rapidly, the rate of resistance to MRSA was 86.6%, MTC50> 4mg / L . MRSA multi-drug resistance is very clear, 96.3% (130/134) of more than 5 kinds of antimicrobial resistance. Methicillin resistant Staphylococcus aureus resistant rate is low. Vancomycin still has good antibacterial activity against MRSA with the antibacterial rate of 100%, MIC50 of 2.28 mg / L and MIC90 of 4.63 mg / L.