This paper is concerned with the well-posedness and large-time behavior of a two-dimensional PDE-ODE hybrid chemotaxis system describing the initiation of tumor angiogenesis.We first transform the system via a Cole-Hopf type transformation into a parabolic-hyperbolic system and then show that the solution to the transformed system converges to a constant equilibrium state as time tends to infinity.Finally we reverse the Cole-Hopf transformation and obtain the relevant results for the pre-transformed PDE-ODE hybrid system.In contrast to the existing related results,where continuous initial data is imposed,we are able to prove the asymptotic stability for discontinuous initial data with large oscillations.The key ingredient in our proof is the use of the so-called“effective viscous flux”,which enables us to obtain the desired energy estimates and regularity.The technique of the“effective viscous flux”turns out to be a very useful tool to study chemotaxis systems with initial data having low regularity and was rarely(if not)used in the literature for chemotaxis models.