目的探讨维生素Ｅ（ＶｉｔＥ）治疗实验性肝纤维化的影响．方法用４００ｍＬ／ＬＣＣｌ４油剂皮下注射９ｗｋ诱导大鼠肝纤维化模型．将３０只肝纤维化大鼠随机分为ＶｉｔＥ治疗组（用ＶｉｔＥ１００ｍｇ／ｋｇ，ｉｖ，２次／ｗｋ，连续２０ｗｋ）、溶剂对照组及空白对照组．观察各组大鼠血清ＡＬＴ、ＡＳＴ、球蛋白（Ｇｌｂ）、丙二醛（ＭＤＡ）、脯氨酸肽酶（ＰＬＤ）及透明质酸（ＨＡ）的变化，并分别于治疗１０和２０ｗｋ取肝组织作病理检查及图象分析．结果大鼠肝纤维化模型形成时上述各项检测指标均显著异常，肝脏大量纤维组织增生．经ＶｉｔＥ治疗１０ｗｋ后，血清ＨＡ（μｇ／Ｌ，６７９±１１５降至３８８±１２９，Ｐ＜００１）显著下降，ＡＳＴ（ＩＵ／Ｌ，３０７±１２８降至６７±２９），Ｇｌｂ（ｇ／Ｌ，４９±６降至２８±６，Ｐ＜００５），ＭＤＡ（μｍｏｌ／Ｌ，１０４±３９降至４５±０９）及ＰＬＤ（Ｕ／Ｌ，４３４８±５７０降至２２１１±８８０）均恢复正常，溶剂及空白对照组各指标虽有下降（ＨＡ，μｇ／Ｌ，５７０±１８７和５９１±１２４，ＡＳＴ，ＩＵ／Ｌ，１３９±５７和１７０±３７，ＭＤＡ，μｍｏｌ／Ｌ，６１±１０和５７±０９，ＰＬＤ，Ｕ? Objective To investigate the effect of vitamin E on experimental hepatic fibrosis. Methods Rat liver fibrosis induced by 9wk was subcutaneously injected with 400mL / L LCCl4 oil. Thirty hepatic fibrosis rats were randomly divided into VitE treatment group (VitE 100mg / kg, iv, twice / wk, continuous 20wk), solvent control group and blank control group. The changes of serum ALT, AST, Glb, MDA, PLD and HA in each group were observed. Tissue for pathological examination and image analysis. Results When the model of rat hepatic fibrosis was formed, all the above indexes were significantly abnormal, and a large number of liver fibrosis proliferated. Serum HA (μg / L, 679 ± 115 to 388 ± 129, P <001) decreased significantly after treatment with VitE for 10 weeks, and AST (IU / L, 307 ± 128 to 67 ± 29), Glb / L, 49 ± 6 to 28 ± 6, P <005), MDA (μmol / L, 104 ± 39 to 45 ± 09) and PLD 570 ± 187 and 591 ± 124, AST, IU / L, 139 ± 57 and 170 ± 37 (HA, μg / L, 570 ± 187 and 591 ± 124, respectively) , MDA, μmol / L, 61 ± 10 and 57 ± 09, PLD, U?