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目的:观察阿司匹林对大鼠糖尿病性白内障的影响。方法:大鼠随机分为A(正常)、B(模型)、C(阿司匹林低剂量)、D(阿司匹林高剂量)4组,B、C、D组以链脲佐菌素建成大鼠糖尿病模型。C、D组分别以低剂量和高剂量阿司匹林灌胃,A、B组给予等量生理盐水。观察不同时期晶状体的变化情况,检测各时间点大鼠晶状体和血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)的变化。结果:与B组相比,C、D组大鼠晶状体混浊程度明显减轻;血清和晶状体中MDA含量明显下降(P<0.05或P<0.01),SOD、GSH-px活性明显增高(P<0.05或P<0.01)。结论:氧化损伤在糖尿病性白内障的发生中起重要作用;阿司匹林抑制糖尿病性白内障形成机制部分为减轻了晶状体的氧化损伤。
Objective: To observe the effect of aspirin on diabetic cataract in rats. Methods: The rats were randomly divided into four groups: A (normal), B (model), C (aspirin low dose) and D (aspirin high dose) . Group C and D were given low dose and high dose of aspirin gavage respectively, and group A and B were given equal volume of saline. The changes of lens in different periods were observed. The changes of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in lens and serum were detected at different time points. Results: Compared with group B, the degree of lens opacity was significantly reduced in group C and group D; the content of MDA in serum and lens decreased significantly (P <0.05 or P <0.01); the activity of SOD and GSH-px increased significantly Or P <0.01). Conclusion: Oxidative damage plays an important role in the development of diabetic cataract. Aspirin inhibits the formation of diabetic cataract in part by reducing the oxidative damage of lens.