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目的采用18F-脱氧葡萄糖(FDG)PET/CT脑显像技术探讨无脑部疾患的体部恶性肿瘤患者的脑葡萄糖代谢异常是否与肿瘤部位有关。资料与方法 20例原发性肝癌和18例胰腺癌患者进行了全身18F-FDG PET检查,采用统计参数地形图软件(SPM)回顾性分析脑部静息葡萄糖代谢资料,并与年龄、性别相匹配的20名健康体检者进行了比较。结果原发性肝癌和胰腺癌患者均存在两侧额叶和颞叶区代谢减低,只是后者所涉及的范围和体素较前者更加广泛,尤其是前额叶皮层;胰腺癌代谢升高的区域也明显较肝癌广泛,前者主要位于两侧海马、海马旁回,杏仁核、前扣带回、后扣带回,小脑亦有广泛的葡萄糖代谢升高,而后者主要集中在扣带后回皮层区域。结论无脑部转移的体部恶性肿瘤患者存在广泛的葡萄糖代谢异常区,这些葡萄糖代息异常区的分布与肿瘤类型有关。
Objective To investigate whether abnormal brain glucose metabolism in patients with brain tumors without brain disease is related to tumor location using 18F-deoxyglucose (FDG) PET/CT brain imaging. Materials and Methods Whole body 18F-FDG PET was performed in 20 cases of primary hepatocellular carcinoma and 18 cases of pancreatic cancer. The statistical parameters of topographical map software (SPM) were used to retrospectively analyze the data of brain glucose metabolism at rest and related to age and gender. The matching 20 healthy checkers were compared. Results Both patients with primary liver cancer and pancreatic cancer had reduced metabolism in both frontal and temporal regions, but the range and voxels involved in the latter were more extensive than those in the former, especially in the prefrontal cortex; areas with elevated metabolism of pancreatic cancer. It is also significantly more common than liver cancer. The former is mainly located on both sides of the hippocampus, parahippocampal gyrus, amygdala, anterior cingulate gyrus, posterior cingulate gyrus, and extensive cerebellar glucose metabolism, while the latter is mainly concentrated in the cingulate cortex. area. Conclusion There is a wide range of glucose metabolism abnormalities in patients with malignant tumors without brain metastases. The distribution of these abnormal glucose cessation areas is related to the type of tumors.