砷对人体具有致癌性,与心血管疾病、糖尿病等疾病有关。砷在体内的代谢是一个极其复杂的过程,而调控砷代谢的相关基因在砷的代谢过程中起到了重要的作用,同时也解释了砷中毒的易感性问题。目前对于砷代谢的过程存在不同学说,对于砷代谢相关基因与砷代谢产物的关系以及砷中毒的易感性等问题,不同地区的报道也有差别。本文就砷甲基化的过程和产物、砷代谢相关基因研究的进展以及今后的研究方向展开阐述。 Arsenic is carcinogenic to the human body and is associated with diseases such as cardiovascular diseases and diabetes. The metabolism of arsenic in the body is an extremely complicated process, and the related genes that regulate arsenic metabolism play an important role in the metabolism of arsenic, and also explain the susceptibility to arsenism. At present, there are different theories about the process of arsenic metabolism. There are also differences in the reports about the relationship between arsenic metabolism related genes and arsenic metabolites and the arsenic poisoning susceptibility. In this paper, the process and products of arsenic methylation, the progress of the research on arsenic metabolism related genes and the future research direction are expounded.