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本文用PAP免疫组织比学法和间接免疫荧光组织化学法,对60例8～38周胎儿胃肠粘膜中胃泌素细胞(G细胞)和生长抑素细胞(D细胞)的发生进行了研究。这两种细胞最早出现于8～9周胎儿十二指肠上皮中,但在固有膜及肌层未观察到。12周后,D细胞出现在胎儿胃肠全长粘膜,G细胞则只见于胃窦及小肠粘膜。本文还对各时期胎儿胃肠粘膜中D细胞和G细胞的分布、数量,以及二者比例变化等进行了观察。胃窦中G细胞与D细胞一样,基底部伸出突起,可能具有旁分泌功能。除胃底腺外,其余部位的D细胞和G细胞多为开放型细胞。本文对这两种细胞在胎儿胃肠发育中的可能功能进行了讨论,并与成人胃窦和十二指肠上部粘膜中G、D细胞的比例进行了对比观察。
In this paper, the PAP immunohistology and indirect immunofluorescence histochemistry in 60 cases of 8 to 38 weeks fetal gastrointestinal mucosa of gastrin cells (G cells) and somatostatin cells (D cells) were studied . These two cells first appeared in 8 to 9 weeks fetal duodenal epithelium, but in the lamina propria and muscular layer was not observed. After 12 weeks, D cells appeared in the fetus full-length gastrointestinal mucosa, G cells were found only in the antrum and small intestine mucosa. This article also on the fetal gastrointestinal mucosa of D cells and G cells in the distribution, the number, as well as the ratio between the two changes were observed. G cells in the gastric antrum and D cells, the base of the Ministry of protrusion, may have paracrine function. In addition to the fundic gland, the rest of the D cells and G cells are mostly open cells. In this paper, the possible functions of these two kinds of cells in fetal gastrointestinal development are discussed, and the proportion of G and D cells in adult gastric antrum and duodenal mucosa is compared.